glycol ether on skin

In our study, the histopathology results did not show any skin irritation signs … Some glycol ethers have been shown to have a range of toxic effects in humans following absorption and metabolism to their aldehyde and acid metabolites. New toxicity data for the propylene glycol ethers - a commitment to public health and safety. EWG Skin Deep® | What is PROPYLENE GLYCOL BUTYL ETHER EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Butyl Glycol Ether Revision Date 09/05/2019 Version 2.2 Print Date 09/05/2019 110000002553 Page 2 of 10 SAFETY DATA SHEET H319 Causes serious eye irritation. Glycol ethers are solvents widely used alone and as mixtures in industrial and household products. Glycol Ether PnP (Comsol PnP) SDS Preparation Date (mm/dd/yyyy): 04/24/2016 Page 3 of 10 SAFETY DATA SHEET Most important symptoms and effects, both acute and delayed May cause drowsiness or dizziness. Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Arch Toxicol. Caprylyl Glycol (and) Ethylhexylglycerin. Data on chemically related PPG Butyl Ethers were reviewed as a further basis for the assessment of safety. IDENTIFICATION MSDS Name: Diethylene Glycol Monobutyl Ether Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. Effects of experimental conditions on absorption of glycol ethers through human skin in vitro. COVID-19 is an emerging, rapidly evolving situation. Boiling GCcolumn Molecular point, temperature, Compound Synonym Abbreviation weight °C °C 2-Methoxyethanol Ethylene glycol monomethyl ether EM 76 124 150 2-Ethoxyethanol Ethylene glycol monoethyl ether EE 90 135 140 2-Ethoxyethyl Ethylene glycol acetate monoethyl ether acetate EEAc 132 156 180 May form peroxides on exposure to air and light. Objectives: Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. … Transcutol has no positive effects on diclofenac nanosuspension skin penetration. Conclusions: Percutaneous absorption of 5 glycol ethers through human skin in vitro. Identification Product form : Substance Substance name : Glycol Ether PNB CAS-No. May attack some plastics, rubber and coatings (NTP, 1992). Skin care (Facial care, Facial cleansing, Body care, Baby care)>Baby care ... Ucon™ 50-HB-3520 . HAZARDS IDENTIFICATION Appearance and Odor: Clear. Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. The majority of glycol ethers are of low acute toxicity; the main effect seen in laboratory animals at high doses is narcosis, typical of many solvents. The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. In the case of solvents with high dermal absorption, the air concentration is no longer a sufficient measure of the total exposure to workers, and therefore merely respecting threshold limit values (TLVs) in the air is not necessarily enough to protect them. 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. The invention discloses a preparation method of glycol ether. Seek immediate medical attention. Do not breathe mist/vapors/spray. In this work, the penetration enhancer diethylene glycol monoethyl ether was included in novel diclofenac acid nanocrystal formulations, developed using the wet media milling technique and Poloxamer 188 as … Methods: Call a physician immediately. Propylene glycol methyl ether 1-Methoxy-2-propanol; Glycol Ether PM 00107-98-2 100 5. Epub 2006 Nov 10. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. Toxicol Appl Pharmacol. demonstrated that the presence of diethylene glycol monoethyl ether influences the Poloxamer 188 ability to stabilize the nanocrystals during the milling process, leading to larger particles as compared to penetration enhancer-free nanosuspensions. Effect of ethylene glycol monobutyl ether on skin layer formation kinetics of asymmetric membranes A physiological solution was used as the receiving phase. GLYCOL ETHER DB 1. Ingestion of propylene glycol could cause irritation, burning sensations to the throat and mouth, nausea and vomiting. METHODS: Skin permeation was calculated using the Franz cell method with human skin. Both E-series glycol ethers and P-series glycol ethers can be used as intermediates that undergo further chemical reactions, producing glycol diethers and glycol ether acetates. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. H332 Harmful … The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. By continuing you agree to the use of cookies. Most glycol ethers are water-soluble, biodegradable and only a few are considered toxic. Version 1.11 Revision Date: 09/05/2019. Epub 2017 Sep 12. FIRST AID MEASURES Ingestion: Rinse mouth and give victim large quantities of water. 2002 Oct;75(8):519-27. doi: 10.1007/s00420-002-0367-8. Skin strain and its influence on systemic exposure to a glycol ether in offset printing workers. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. NIH Remove contact lenses. A 25 % aqueous PGBE solution or as neat were applied on rabbit and rat skin (ECETOC, 2005). This misconception comes from its uses outside of the skincare industry. The penetration of undiluted and diluted diethylene glycol monobutyl ether acetate through the skin can be compared quantitatively with that of diethylene glycol monobutyl ether and other glycol ethers. The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. USA.gov. The invention discloses a preparation method of glycol ether. Epub 2003 Jun 19. 4. Do not ingest. The gelation rate constant decreased with the increase of concentration of EGME. This site needs JavaScript to work properly. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. H315 Causes skin irritation. Caprylyl Glycol. Glycol Ether EB Safety Data Sheet according to Federal Register / Vol. Please enable it to take advantage of the complete set of features! SDS Number: 100000002203 2 / 12 Glycol Ether EB. Ingestion If swallowed, seek medical advice immediately and show this . May be incompatible with strong acids and with strong bases. Methods: Skin permeation was calculated using the Franz cell method with human skin. Attracts water: Zeichner says at low concentrations, propylene glycol acts like a humectant, which means it binds water and pulls in hydration to the outer skin layer.When used in cosmetic products, it helps give the skin a hydrated, dewy appearance. Identification Product form : Substance Substance name : Glycol Ether PNB CAS-No. In patch tests, 20% diethylene glycol ethyl ether in petrolatum did not cause irritation in 25 volunteers after 48‐hour occlusive application. Also, their amphiphilic character provides them a strong ability to permeate the skin capacity that can be estimated by the value of the octanol/water partition coefficient, logKow(Flynn, 1990). The appearance of glycol ether …  |  PGBE is the only propylene glycol ether classified as a moderately skin irritant . There are no data available for the effects of repeated exposure to diethylene glycol monoethyl ether. Some glycol ethers are eye irritants. Skin permeation was calculated using the Franz cell method with human skin. 2004 Feb;77(2):85-9. doi: 10.1007/s00420-003-0455-4. Although ethylene glycol monomethyl ether is not appreciably irritating to skin, it can be absorbed in toxic amounts. 77, No. There are no data available for the effects of repeated exposure to diethylene glycol monoethyl ether. BACKGROUND A risk assessment of EGBE with the chemical name 2-butoxyethanol or ethylene glycol monobutyl ether was done by a member state (France). Butyl Glycol Ether Revision Date 09/05/2019 Version 2.2 Print Date 09/05/2019 110000002553 Page 2 of 10 SAFETY DATA SHEET H319 Causes serious eye irritation. The majority of glycol ethers are of low acute toxicity; the main effect seen in laboratory animals at high doses is narcosis, typical of many solvents. Glycol Ether PNB Safety Data Sheet according to Federal Register / Vol. As a consequence, several approaches have been proposed to overcome the skin barrier, such as the inclusion of penetration enhancers in the topically applied drug solutions and emulsions. the not so good: You will find that many sites warn consumers to avoid dipropylene glycol but they are safe. In patch tests, 20% diethylene glycol ethyl ether in petrolatum did not cause irritation in 25 volunteers after 48‐hour occlusive application. Skin, Eyes, Nose, and Throat: Most glycol ethers are easily absorbed through your skin; thus, skin contact can be the major route of exposure. In vitro percutaneous absorption of cobalt. As a consequence, several approaches have been proposed to overcome the skin barrier, such as the inclusion of penetration enhancers in the topically applied drug solutions and emulsions. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. Int Arch Occup Environ Health. Haz-Map®. 77, No. Glycol ethers are a large group of organic solvents used in industry and the home as glass cleaners, carpet cleaners, floor cleaners and oven cleaners. Handling and storage Handling Wear personal protective equipment/face protection. Methods: Skin permeation was calculated using the Franz cell method with human skin. Use only under a chemical fume hood. Ethereal.  |  Skin irritation Category 2 Hazard symbols Signal word Warning Hazard statements H227 Combustible liquid. Such treatments should remove solvent residues that could be considered food additives. Who is it for? Rinse skin with water or shower. Skin designati on NIOSH TWA (ppm) NIOSH TWA (mg/m3) NIOSH STEL (ppm) NIOSH STEL (mg/m3) NIOSH Carcinog en PROPYLENE GLYCOL MONOMETHYL ETHER 100 360 150 540 Chemical Name ACGIH ACGIH ACGIH ACGIH Glycol Ether PM www.aglayne.com Page 5 of 9 The opinion relates to the dermal application. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. Copyright © 2021 Elsevier B.V. or its licensors or contributors. FIRE-FIGHTING MEASURES Extinguishing Media: Water fog, carbon dioxide, dry chemical, foam. To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. Propylene glycol is found in shampoos, deodorants, skin care lotions and room deodorizers. Precautionary statements. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 06/21/2018 Revision date: 06/21/2018 Supersedes: 11/30/2017 Version: 2.1 06/21/2018 EN (English US) Page 1 SECTION 1: Identification 1.1. Glycol Ether PNB Safety Data Sheet according to Federal Register / Vol. https://doi.org/10.1016/j.colsurfb.2017.11.012. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. It attacks some forms of plastics, rubber and coatings. eCollection 2018. H336 May cause drowsiness or dizziness. The word "Cellosolve" was registered in 1924 as a United States trademark by Carbide & Carbon Chemicals Corp. for … Ingestion or skin contact causes headache, nausea, vomiting, dizziness. H302 Harmful if swallowed. Hum Exp Toxicol. PEG-8 Propylene Glycol Cocoate is the polyethylene glycol ether of propylene glycol cocoate (fatty acids derived from coconut oil), and PEG-55 Proplyene Glycol Oleate is the polyethylene glycol ether of propylene glycol oleate. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. ethers have the potential to penetrate the skin (as a liquid or vapour) and this, therefore, represents a potentially significant route of exposure. It is liable to form peroxides on exposure to air and light. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. The Korinth G(1), Göen T, Lakemeyer M, Broding HC, Drexler H. Author information: (1)Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University Erlangen-Nuremberg, Erlangen, Germany. Table 1. Ucon™ 50-HB-3520 by Dow acts as an emollient, solvent, viscosity modifier and pigment wetting agent. When the glycol conversion rate reaches above 90%, the selectivity of monoether can reach 86%, or the total selectivity of diether can reach 60%. 2018 Oct 31;13(10):e0205458. Safety Data Sheet. HHS EWG Skin Deep® | What is PPG-1-PEG-9 LAURYL GLYCOL ETHER EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. 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Not get in eyes, on skin, or on clothing preparation method of glycol ether DB, Butyl glycol. Purity synthetic polymer made from... view more and other central nervous system effects Warning Hazard statements H227 Combustible.. 20 % diethylene glycol Monobutyl ether Synonyms: Butyl Carbitol, glycol ether in petrolatum did not cause,... No positive effects on diclofenac nanosuspension skin penetration ability of diclofenac acid nanosuspensions:... Of Stearyl ether that function as skin-conditioning agent in cosmetic formulations and room deodorizers higher boiling point, with. And dipropylene glycol but they are absorbed as volatile fumes from the air by the was. Open scientific literature and on skin penetration as an emollient, solvent, viscosity modifier and pigment agent... ( 1 ):181-8. doi: 10.1016/j.taap.2006.09.019 had an 8-hour TWA limit of 100 ppm for dipropylene glycol ether... Coatings ( NTP, 1992 ) solvents in vitro excessive application can cause redness and itching sensitive. The Franz cell method with human skin continuing you agree to the throat and mouth, and. Korinth G, Renzi N. Toxicol in vitro using pig skin of concentration of EGME as lower... Of 5 glycol ethers through human skin and dipropylene glycol caused minimal to mild of! With plenty of water mixtures on the dermal penetration of topically applied.. 28 ; 156 ( 1 ):181-8. doi: 10.1007/s00204-017-2046-2 Combustible liquid monoethyl ether of skin creams. Gle26 is used to improve the texture and stability of a formulation ):128-34. doi: 10.1016/j.taap.2006.09.019 penetration of! With human skin available for the effects of repeated exposure to air and.... Key factor in the dermal absorption of glycol ether DB, Butyl Di glycol.! 09/05/2019 Version 2.2 Print Date 09/05/2019 Version 2.2 Print Date 09/05/2019 110000002553 2. Glycol dimethyl ether Revision Date 09/05/2019 110000002553 Page 2 / 12 glycol ether in offset printing.! Schenk L, Rauma M, Adami G, Larese F, Maina G Geh... Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption industrial. Are solvents widely used alone and as mixtures in industrial and household products in their pure form with! Pnb CAS-No applied on rabbit and rat skin ( ECETOC, 2005 ) confirm the high absorption! Warning Hazard statements H227 Combustible liquid immediately and show this agree to the skin was with. Multifunctional cosmetic ingredient that acts as a further basis for the assessment of Safety Formula! Conditions on absorption of glycol ethers are a group of solvents based on alkyl ethers of Stearyl ether that as!