doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. How effective is it? It’s important for many functions in the body, especially making and breaking down fats. In an older clinical study, acne vulgaris was effectively treated with both oral and topical pantothenic acid in 100 patients.6 Mucocutaneous adverse reactions caused by isotretinoin therapy have been effectively treated with dexpanthenol 5% cream.7 A pilot study found dexpanthenol 5% as effective as hydrocortisone in atopic dermatitis.8. 10 In addition to its uses, pantothenic acid may also provide the … what signs you had. During pregnancy and lactation, the adequate intake is pantothenic acid 6 and 7 mg/day, respectively. In the body, pantothenic acid is converted to the related chemical pantethine, the biologically active form. This information relates to an herbal, vitamin, mineral or other dietary supplement. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. biotin, multivitamin, ascorbic acid, calcium / vitamin d, Fish Oil. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Calcium pantothenate uses Pantothenic acid is frequently used in combination with other B vitamins in vitamin B complex formulations. You will need to talk about the benefits and risks of using pantothenic acid Take a missed dose as soon as you think about it. Vitamin B5, also called pantothenic acid, is one of 8 B vitamins. Pantothenic acid is a vitamin, also known as vitamin B5, used as a dietary supplement when taken in recommended daily allowances (RDAs), and also to treat pantothenic acid deficiency. advice about side effects. If you have an allergy to pantothenic acid or any other part of pantothenic acid. Pantothenic acid is available under the following different brand and other names: Vitamin B5. Despite positive findings in rodent studies, little positive clinical data exist regarding the use of pantothenic acid in the condition or growth of human hair. while you are pregnant. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. When dosed above the recommended dietary allowance (6 to 7 mg/day), pantothenic acid is designated Category C. None well documented. We comply with the HONcode standard for trustworthy health information -, http://www.ncbi.nlm.nih.gov/books/NBK114311/. Nonetheless, it is generally used as a dietary supplement, first and foremost. Pantothenic acid also plays a role in the production of coenzyme A, which is responsible for many biochemical reactions, including the synthesis and oxidation of fatty acids, as well as the uptake of drugs and toxins in the liver. These B vitamins, often referred to as B complex vitamins, also help the body use fats and protein. Pantothenic acid and its derivatives may have a role in the management of dyslipidemia and in wound healing. This information should not be used to decide whether or not to take this product. Tell your Clinical studies have used pantethine 600 to 1,200 mg/day for dyslipidemia, 200 to 300 mg/day for wound healing, and 1.5 g/day for exercise performance; typically, a dosage of 300 mg 3 times daily is recommended.15, 16, 37, 38, Pantothenic acid has been assigned US FDA Pregnancy Category A (ie, adequate, well-controlled studies have failed to demonstrate a risk to the fetus). Tell your doctor about the allergy and Supplemental Uses. It is essential for the biosynthesis of coenzyme A, which plays a critical role in the metabolism of carbohydrates, proteins, and lipids. Pantothenic acid is chemically unstable, hygroscopic, viscous oil, sensitive to acids, bases, and heat. It is sweet with a bitter aftertaste. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There may be drug take-back programs in your area. Athletic performance. In a 1998 review, the Institute of Medicine did not set a tolerable upper intake level for pantothenic acid because reports of adverse effects are lacking. Pantothenic acid is a member of the B-complex of vitamins and is essential for the biosynthesis of coenzyme A, an important substance involved in energy release from carbohydrates; metabolism of amino acids and fatty acids; syntheses of compounds, including sterols, steroid hormones, and acetylcholine; and other reactions. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Knowledge of pantothenic acid resulted from experimentation on microorganisms and chicks. We comply with the HONcode standard for trustworthy health information -. Pantothenic acid is used in the synthesis of CoA via a five-step process that requires pantothenic acid, four molecules of ATP and cysteine (see figure). However, potential benefits may justify the potential risks). In high doses, pantothenic acid may inhibit the absorption of biotin produced by the microflora in the large intestine. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. It can also be used in supplements to treat Vitamin B5 deficiencies. Caution may be warranted with concomitant use of biotin. The vitamin was first isolated in 1931, and its role as an essential component in the growth of yeast cells was demonstrated in 1933. If your symptoms or health problems do not get better or if they become worse, call your doctor. B5 is another of the B family. It is also essential in producing, transporting, and releasing energy from fats. Available for Android and iOS devices. It is used to make coenzyme A (CoA), a chemical compound that helps enzymes to build and break down fatty acids as well as perform other metabolic functions, and acyl carrier protein, which is also involved in building fats. It can also be applied to the skin to relieve itchiness and promote healing from skin conditions, such as: eczema insect bites poison ivy diaper rash Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Common sources of pantothenic acid include liver, queen bee jelly, yeast, rice bran, molasses, peanuts, tree nuts, whole grains, mushrooms, eggs, milk, and potatoes. Vitamin B5 deficiency is extremely rare in people as pantothenic acid is found in nearly … any drug without checking with your doctor. Signs of an allergic reaction, like rash; Store in a dry place. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not share your drugs with others and do not take anyone else's drugs. Lowered food intake, body weight, insulin, glucose, and triglyceride levels, as well as decreased cholesterol and improvements in other parameters have been demonstrated with use of pantethine in animal experiments.9, 10, 11, 12, 13, 14, A review of pantethine's use as a nutraceutical option for the treatment of hypertriglyceridemia as well as a meta-analysis of pantethine's efficacy and tolerability covering 28 studies from 1966 to 2002 was published. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Pantothenic acid is important for our bodies to properly use carbohydrates, proteins, and lipids and for healthy skin. If you are allergic to pantothenic acid; any part of pantothenic acid; or any other drugs, foods, or substances. Vitamin B5, or pantothenic acid, is naturally present in foods, added to foods, and available as a supplement. Uses Pantothenic acid, also called vitamin B5, is a water-soluble vitamin involved in the Kreb's cycle of energy production and is needed to make the neurotransmitter acetylcholine. Pantothenic acid is used to treat pantothenic acid deficiency. This breaks down fatty acids, triglycerides, and cholesterol in your body. Like the other complex B vitamins, vitamin B-5 plays a vital role in helping the human body maintain good health. Your body needs vitamin B5 to. It occurs naturally in the body and can be ingested through several food sources including meats, whole grains, vegetables such as broccoli, avocados, mushrooms, and sweet potatoes, egg yolks, milk, and yogurt. Clinical studies have used pantothenic acid 600 to 1,200 mg/day for dyslipidemia. The main function of this water-soluble B vitamin is in the synthesis of coenzyme A (CoA) and acyl carrier protein [ 1, 2 ]. You may also report side effects at https://www.fda.gov/medwatch. If you are allergic to pantothenic acid; any part of pantothenic acid; or any other drugs, foods, or substances. Improves Lipid Profile. Do not flush down a toilet or pour down a drain unless you are told to do so. Human studies are lacking, and animal studies are either positive for fetal risk or lacking. Call your doctor for medical What do I need to tell my doctor BEFORE I take Pantothenic Acid? This includes your doctors, nurses, pharmacists, and dentists. Vitamin B5 is commercially available as D-pantothenic acid, as well as dexpanthenol and calcium pantothenate, which are chemicals made in the lab from D-pantothenic acid. Pantothenic acid is optically active, with maximum biological activity only in the D-form. Dexpanthenol, a chemical similar to pantothenic acid, is used for skin irritation, nasal swelling and irritation, and other conditions, but there is no good scientific research to support these uses. pharmacist if you have questions about the best way to throw out drugs. An oral median lethal dose of 10 g/kg for mice has been reported. No benefit was seen for exercise performance, muscle coenzyme A levels, or fuel selection.40, The US RDA for pantothenic acid in nutritional supplements and foods is age dependent and ranges from 0.2 mg/kg in infants to 5 mg in adults. Tell all of your health care providers that you take pantothenic acid. Pantothenic acid is safe and effective for individuals with high level of total … It is sweet with a bitter aftertaste. Dexpanthenol as a pastille and as a spray has been evaluated in small clinical trials for wound healing in postoperative tonsillectomy, endotracheal intubation, and endoscopic sinus surgery.25, 26, 27 Increased hydration due to dexpanthenol may explain the positive effects, or a possible increase in the number of dermal fibroblasts.2 An evidence-based review of the benefit of vitamin supplements for wound healing identified data on the combination of ascorbic acid and pantothenic acid for surgical wounds. Call your doctor or get medical This is called metabolism. Be ready to tell or show what was Do not take 2 doses at the same time or extra doses. Medically reviewed by Drugs.com. Pantethine stimulates GI motility in laboratory animals.28, 29 A clinical role for this effect has not been established, and no efficacy in treating ulcerative colitis was found in a small open-label study.30, Dexpanthenol has been used intravenously in combination with other micronutrients ("Myers' Cocktail") in fibromyalgia31 and in arthritis in older studies.2, Older studies in animals suggest that pantothenic acid increases levels of coenzyme A and glutathione, protecting against oxygen-radical species and ionizing radiation as well as against induced hepatotoxicity.32, 33, A role for pantothenic acid in epilepsy therapy34 and in exercise performance have not been pursued to any extent in the literature.35, A small study (n = 8) looked at the effective of daily doses of 1.5 g of pantothenic acid combined with an equal amount of L-cysteine. to make sure that it is safe for you to take pantothenic acid with all of your drugs and health problems. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Pantothenic acid is converted to pantethine in the body. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Follow your doctor's orders or the directions on the label. Attention deficit-hyperactivity disorder (ADHD). Pantothenic acid is widely used in skin and hair care products and also in medicines and supplements for oral consumption. Clinical studies are limited. The following information includes only the average doses of this medicine. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Pantothenic acid is commercially available as D-pantothenic acid and its synthetic derivatives dexpanthenol and calcium pantothenate. Pantothenic Acid, which is also known as pantothenate, or simply vitamin B5, is a water soluble vitamin in the B vitamin family. This is only a brief summary of general information about this product. More than anything else, vitamin B5 helps keep the skin healthy and attractive in … A case report of life-threatening eosinophilic pleuropericardial effusion with concomitant use of biotin 10 mg/day and pantothenic acid 300 mg/day exists.37, In high doses, pantothenic acid may inhibit the absorption of biotin produced by microflora in the large intestine; diarrhea may occur. Another example, published in the International Journal for Vitamin and Nutritional Research, found that higher quantities of pantothenate enhance wound healing. Some drugs may have another patient information leaflet. Pantothenic acid (also known as vitamin B5) is an essential nutrient that is naturally present in some foods, added to others, and available as a dietary supplement. Diarrhea may occur with large doses of pantothenic acid. Symptoms include fatigue, apathy, sleep disturbances, GI symptoms, numbness and paresthesias, muscle cramps, and hypoglycemia.1, 2, 3 Pantothenic acid was given to prisoners of war in Asia during World War II to alleviate Grierson-Gopalan syndrome, also known as burning feet syndrome, now essentially unknown and thought to be due to malnutrition.1, 2. Do not store in a bathroom. Medically reviewed by Drugs.com. biotin, multivitamin, ascorbic acid, calcium / vitamin d, Fish Oil. Liquid preparations of pantothenic acid are commercially available as D-pantothenyl alcohol or panthenol.1, 2. Pantothenic acid and biotin are needed for growth. This information is not specific medical advice and does not replace information you receive from your health care provider. The body uses it to breakdown carbohydrates, proteins and fats and turn them into glucose so the body can then use it for fuel. Select one or more newsletters to continue. taken, how much, and when it happened. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Generic Name: Pantothenic Acid (pan toe THEN ik AS id)Brand Name: Panto-250. The meta-analysis suggests that pantethine may be effective in treating individuals with cholesterol levels greater than 200 mg/dL and/or serum triglyceride levels greater than 150 mg/dL. Scientific Name(s): D(+)-alpha-(-dihydroxy-beta,beta-dimethylbutyryl-beta-alanaine)Common Name(s): Antidermatitis vitamin, Calcium-pantothenate, D-pantothenic acid, Dexpanthenol, Pantethine, Pantothenate, Pantothenic acid, Vitamin B5. Or change the dose of 10 g/kg for mice has been an overdose, call your doctor tells to. Category C. 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